Integrin Traffic and Signalling – from Plasma Membrane to Endosomes
نویسندگان
چکیده
4 Jonna Alanko Integrin traffic and signalling – from plasma membrane to endosomes From the Department of Biochemistry, University of Turku, Turku Centre for Biotechnology, VTT Technical Research Centre of Finland, Doctoral Programme of Biomedical Sciences and Doctoral Programme in Molecular Life Sciences, University of Turku, Finland.
منابع مشابه
Distinct Recycling of Active and Inactive β1 Integrins
Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins undergo constant endo/exocytic shuttling to facilitate the dynamic regulation of cell adhesion. Integrin activity toward the components of the extracellular matrix is regulated by the ability of these receptors to switch between active and inactive conformations. Several cellular signalling pathways hav...
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Integrin trafficking from and to the plasma membrane controls many aspects of cell behavior including cell motility, invasion, and cytokinesis. Recruitment of integrin cargo to the endocytic machinery is regulated by the small GTPase Rab21, but the detailed molecular mechanisms underlying integrin cargo recruitment are yet unknown. Here we identify an important role for p120RasGAP (RASA1) in th...
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Collagen receptor integrins recycle between the plasma membrane and endosomes and facilitate formation and turnover of focal adhesions. In contrast, clustering of α2β1 integrin with antibodies or the human pathogen echovirus 1 (EV1) causes redistribution of α2 integrin to perinuclear multivesicular bodies, α2-MVBs. We show here that the internalized clustered α2 integrin remains in α2-MVBs and ...
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Compensatory endocytosis (CE) ensures recycling of membrane components and maintenance of plasma membrane size; however, the mechanisms, regulation, and physiological functions of clathrin-independent modes of CE are poorly understood. CE was studied in umbrella cells, which undergo regulated exocytosis of subapical discoidal/fusiform vesicles (DFV) during bladder filling, and may then replenis...
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To identify kinases that regulate integrin recycling, we have immunoprecipitated avb3 integrin from NIH 3T3 fibroblasts in the presence and absence of primaquine (a drug that inhibits receptor recycling and leads to accumulation of integrins in endosomes) and screened for co-precipitating kinases. Primaquine strongly promoted association of avb3 integrin with PKD1, and fluorescence microscopy i...
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